The Effects of Calina Papaya Leaf Ethanol Extract On Estrus Cycle And Uterus Morphology of Wistar Rats

Calina papaya leaf is an Indonesian plant type that has the potential to be used as a medicinal plant. Phytochemical compounds found in leaves act antifertility agents. The research aimed study effect of ethanol extract on estrus cycle and uterine morphology wistar rats. experiment lasted 30 days involved 25 female treatment consisted 5 groups, namely K (distilled water), K+ (contraceptive pill), P1 (Calina 200mg/KgBW), P2 300mg/KgBW), P3 400mg/KgBW). parameters phase, total ratio. Uterus morphological consist wall thickness endometrium, myometrium, perimetrium. examination was carried out every day using vaginal smear method (Giemsa 5%). On 31st day, surgery performed uterus taken for histological observation paraffin (HE staining). Data were analyzed One Way ANOVA with further Duncan’s test. results showed dose 400 mg/KgBW could affect accelerate phase increase ratio compared control (P0.05). There decrease endometrium myometrium at conclusion natural agent